Metabolic syndrome at 6 weeks after delivery in a cohort of pre-eclamptic and normotensive women
Background. The association between pre-eclampsia and the subsequent development of metabolic syndrome has not been well documented in low- and middle-income countries.
Objectives. To compare the prevalence of metabolic syndrome at 6 weeks after delivery among women with pregnancies complicated by pre-eclampsia with that in a normotensive, low-risk control group in an urban South African (SA) setting.
Methods. This was a prospective cohort study at two tertiary-level hospitals and one district-level hospital in Pretoria, SA. Women were recruited after delivery and were followed up 6 weeks later to confirm or exclude the diagnosis of metabolic syndrome.
Results. Metabolic syndrome was diagnosed in 48/150 women with pregnancies complicated by pre-eclampsia (32.0%), compared with 33/150 (22.0%) of the control group (p=0.05).
Conclusions. Women who developed pre-eclampsia during pregnancy had an increased chance of metabolic syndrome being diagnosed 6 weeks after delivery. Guidelines should be developed to identify women with cardiometabolic risk, so that interventions may be implemented to modify this risk before and after pregnancy.
P Ntlemo, Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, University of Pretoria and Steve Biko Academic Hospital, Pretoria, South Africa
T Cronje, Department of Statistics, Faculty of Natural and Agricultural Sciences, University of Pretoria, South Africa
P Soma-Pillay, Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, University of Pretoria and Steve Biko Academic Hospital, Pretoria, South Africa; South African Medical Research Council Maternal and Infant Health Care Strategies Unit, Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa
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Date published: 2021-03-31
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