Review

The impact of obesity on the cellular and molecular pathophysiology of COVID-19

P Dhanraj, R Pitere, M S Pepper

Abstract


Emerging evidence reveals a strong association between COVID-19 and obesity in terms of disease severity, need for hospitalisation and risk of mortality. In this review, we discuss cellular and molecular mechanisms potentially contributing to the pathophysiology of COVID-19 in obese patients. Understanding the relationship between COVID-19 and obesity is pertinent for the clinical management of these patients.


Authors' affiliations

P Dhanraj, Department of Immunology, Institute for Cellular and Molecular Medicine, SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, South Africa

R Pitere, Department of Immunology, Institute for Cellular and Molecular Medicine, SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, South Africa

M S Pepper, Department of Immunology, Institute for Cellular and Molecular Medicine, SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, South Africa

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Keywords

COVID-19; SARS-CoV-2; Obesity; Immune response; ACE2

Cite this article

South African Medical Journal 0;0(0):. DOI:10.7196/SAMJ.2021v111i2.15398

Article History

Date submitted: 2020-12-14
Date published: 2020-12-14

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