Centenary of the UCT Faculty of Health Sciences
Lowering the alcohol content of red wine does not alter its cardioprotective properties
Abstract
Aims. The antioxidant and cardioprotective properties of a French red wine (cabernet sauvignon, 12% alcohol by volume) were compared with those of the same wine subjected to reverse osmosis for partial removal of alcohol (6% alcohol by volume).
Methods. Antioxidant capacity was assessed in vitro using the oxygen radical absorbance capacity (ORAC) assay. To test the cardioprotective effect of 12% v. 6% wine, the drinking water of rats used for controls was supplemented with red wine (12% or 6%). After 10 days, hearts were isolated on a Langendorff system and subjected to 30 minutes of global ischaemia plus 30 minutes of reperfusion (I/R).
Results. No differences in antioxidant capacity were observed between wine of 12% and 6% alcohol content (n=8 per group). Control hearts subjected to I/R presented a rate pressure product (heart rate x left ventricular developed pressure, expressed as a percentage of baseline value) of 16±4% (mean±standard error). Pretreatment with wine 12% or 6% improved the rate pressure product to 40±6% and 43±6%, respectively (p<0.05 v. control).
Conclusion. Our findings suggest that the reduction of alcohol content from 12% to 6% in wine did not alter its antioxidant and cardioprotective properties. Moderate and regular consumption of lower alcohol content wines may confer beneficial effects without the risks associated with traditional wines of higher alcohol content.
Authors' affiliations
Kim Lamont, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, University of Cape Town
Dee Blackhurst, Division of Chemical Pathology, Clinical Laboratory Sciences, University of Cape Town
Zulfah Albertyn, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, University of Cape Town
David Marais, Division of Chemical Pathology, Clinical Laboratory Sciences, University of Cape Town
Sandrine Lecour, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, University of Cape Town
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Article History
Date published: 2012-05-23
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