Scientific letters

A historical review of XDR tuberculosis in the Western Cape province of South Africa

Gregory Symons, Karen Shean, Elize Pietersen, Richard van Zyl Smit, Lititia Pool, Malika Davids, Paul Willcox, Keertan Dheda

Abstract


There are limited data on the temporal relationship between the regional introduction of multidrug-resistant tuberculosis (MDR-TB) treatment and the subsequent development of extensively drug-resistant TB (XDR-TB). The first XDR-TB case in the Western Cape province of South Africa was recorded in 1992, approximately 5 - 7 years after the regional introduction of MDR-TB-like treatment. Between 1990 and 2002 we identified 48 patients with XDR-TB in the Cape Metropole region of the Western Cape province. Patients were predominantly HIV-uninfected and median survival was 10.8 months. XDR-TB has therefore been present in the Western Cape at least since 1992. These data inform public health policy relevant to the introduction of new anti-TB drug regimens.

Authors' affiliations

Gregory Symons, UCT Lung Institute, GSH Department of Medicine

Karen Shean,

Elize Pietersen,

Richard van Zyl Smit,

Lititia Pool,

Malika Davids,

Paul Willcox,

Keertan Dheda,

Full Text

PDF (169KB)

Keywords

Drug-resistant TB, XDR TB, South Africa, History

Cite this article

South African Medical Journal 2011;101(9):636,638.

Article History

Date submitted: 2011-07-26
Date published: 2011-09-05

Article Views

Abstract views: 1073
Full text views: 927

Comments on this article

*Read our policy for posting comments here