Research

The prevalence of coeliac disease-associated human leukocyte antigens in South African transplant donors and recipients

K L Mrubata, P Barrow, E Mayne, D Nelson, T De Maayer

Abstract


Background. Coeliac disease (CD) is an autoimmune condition occurring in genetically predisposed individuals exposed to an environmental trigger. The human leukocyte antigen (HLA) haplotypes HLA-DQ2.5 and HLA-DQ8 have the strongest association with CD, and 90 - 95% of CD patients bear these haplotypes. The susceptibility of the South African (SA) population to CD has not been studied previously.

Objectives. To describe the genetic propensity of the SA population to CD.

Methods. The South African National Blood Service database was used to analyse the prevalence of HLA-DQ2.5 and HLA-DQ8 in potential donors and recipients of organ transplants. Self-reported ethnic group was used to estimate the prevalence among different population groups.

Results. The overall prevalence of HLA-DQ2.5 and HLA-DQ8 was 19.8%. The prevalence was lower in black participants (15.9%) than in whites (28.6%). Coloured (22.0%) and Indian (17.4%) participants had an intermediate prevalence. There was no significant difference between potential transplant donors and recipients.

Conclusions. The prevalence of HLA-DQ2.5 and HLA-DQ8 differed among SA study participants of different ethnicities. However, the notion that CD does not occur in black South Africans owing to lack of a genetic predisposition is incorrect.


Authors' affiliations

K L Mrubata, Department of Paediatrics, Rahima Moosa Mother and Child Hospital and Department of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

P Barrow, Wits Donald Gordon Medical Centre, Johannesburg, South Africa

E Mayne, Department of Immunology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa

D Nelson, Specialised Laboratory Service, South African National Blood Service, Johannesburg, South Africa

T De Maayer, Department of Paediatrics, Rahima Moosa Mother and Child Hospital and Department of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Full Text

PDF (120KB)

Keywords

Coeliac disease; HLA class II alleles; South Africa

Cite this article

South African Medical Journal 2021;111(10):991-994. DOI:10.7196/SAMJ.2021.v111i10.15680

Article History

Date submitted: 2021-10-05
Date published: 2021-10-05

Article Views

Abstract views: 738
Full text views: 427

Comments on this article

*Read our policy for posting comments here