Festschrift: Peter Beighton

A possible heterozygous advantage in muscular dystrophy

A E H Emery


In certain autosomal recessive disorders there is suggestive evidence that heterozygous carriers may have some selective advantage over normal homozygotes. These include, for example, cystic fibrosis, Tay-Sachs disease and phenylketonuria. The best example so far, however, is that of significant heterozygous advantage in sickle-cell anaemia with increased resistance to falciparum malaria.



Author's affiliations

A E H Emery, Green Templeton College, University of Oxford, Oxford, UK; and University of Edinburgh, Scotland

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Cite this article

South African Medical Journal 2016;106(6):S65. DOI:10.7196/SAMJ.2016.v106i6.10998

Article History

Date submitted: 2016-05-06
Date published: 2016-05-25

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