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Burkitt’s lymphoma patients in Northwest Cameroon have a lower incidence of sickle cell trait (Hb AS) than healthy controls

P B Hesseling, D T Jam, D D Palmer, P Wharin, G S Tuh, R Bardin, M Kidd

Abstract


Contradictory findings have been reported from Africa with regard to the risk of developing Burkitt’s lymphoma (BL) in sickle cell trait (AS)
carriers. Haemoglobin electrophoresis was performed in 78 BL patients in the Northwest region of Cameroon, and in 78 nearest-neighbour
controls of the same age, sex and tribe from the same village. AS was confirmed in 4 of 78 (5.13%) BL patients and in 11 of 78 (14.10%)
controls (χ2, p=0.052; Fisher’s exact, one-tailed, p=0.050). Sickle cell trait carriers had a marginal statistically reduced risk of developing BL.



Authors' affiliations

P B Hesseling, Department of Paediatrics and Child Health, Tygerberg Children’s Hospital, Stellenbosch University, Cape Town

D T Jam, Mbingo Baptist Hospital, Mbingo, Northwest region

D D Palmer, Mbingo Baptist Hospital, Mbingo, Northwest region

P Wharin, Beryl Thyer Memorial Africa Trust, Warkton

G S Tuh, Mbingo Baptist Hospital, Mbingo, Northwest region

R Bardin, Mbingo Baptist Hospital, Mbingo, Northwest region

M Kidd, Department of Biostatistics, Stellenbosch University, Cape Town

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Keywords

Burkitt's lymphoma; Cameroon; Sickle cell trait; Hb AS

Cite this article

South African Medical Journal 2016;106(7):686. DOI:10.7196/SAMJ.2016.v106i7.10693

Article History

Date submitted: 2016-02-19
Date published: 2016-06-17

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