Continuing Medical Education

A clinical update on paediatric lupus

Graeme William Spittal, Laura B Lewandowski, Chris Scott

Abstract


Systemic lupus erythematosus in children is a life-threatening chronic disease that is being increasingly recognised. More black African
children are being diagnosed and the proportion of males affected is much higher than in adult-onset lupus. The presenting manifestations
of childhood-onset lupus are variable and many systems are involved. Children with lupus often present late with severe disease, and in
South African (SA) children severe lupus nephritis occurs commonly at presentation. The investigations for lupus should be performed in
a three-step process – initial essential investigations, antibody and serological tests, and supplementary investigations.
The most important factor in the management is to involve a multidisciplinary team as soon as possible. All cases of lupus in SA should be discussed
with a paediatric specialist so that a tailored management plan can be made, depending on the presenting features and course of the disease.


Authors' affiliations

Graeme William Spittal, Paediatric Rheumatology, Red Cross War Memorial Children’s Hospital, University of Cape Town, South Africa

Laura B Lewandowski, Pediatric Rheumatology, Duke University Medical Center, Durham, NC, USA

Chris Scott, Paediatric Rheumatology, Red Cross War Memorial Children’s Hospital, University of Cape Town, South Africa

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Keywords

Paediatric lupus

Cite this article

South African Medical Journal 2015;105(12):1075. DOI:10.7196/SAMJ.2015.v105i12.10341

Article History

Date submitted: 2015-11-13
Date published: 2015-11-16

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